![]() Prospective studies with cardiac arrest patients indicate that the incidence of NDEs vary between 2–18% depending on what criteria are used to determine them ( Parnia et al., 2001 Van Lommel et al., 2001 Schwaninger et al., 2002 Greyson, 2003). Near-death experiences (NDEs) are complex experiential episodes that occur in association with death or the perception that it is impending ( Moody, 1975 Greyson, 1983). These results reveal a striking similarity between these states that warrants further investigation. Furthermore, we found a significant overlap in nearly all of the NDE phenomenological features when comparing DMT-induced NDEs with a matched group of ‘actual’ NDE experiencers. Also, we found significant relationships between the NDE scores and DMT-induced ego-dissolution and mystical-type experiences, as well as a significant association between NDE scores and baseline trait ‘absorption’ and delusional ideation measured at baseline. Results revealed significant increases in phenomenological features associated with the NDE, following DMT administration compared to placebo. In this within-subjects placebo-controled study we aimed to test the similarities between the DMT state and NDEs, by administering DMT and placebo to 13 healthy participants, who then completed a validated and widely used measure of NDEs. Potential similarities between both subjective states have been noted previously, including the subjective feeling of transcending one’s body and entering an alternative realm, perceiving and communicating with sentient ‘entities’ and themes related to death and dying. Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more specifically with the experience induced by the potent serotonergic, N, N-Dimethyltryptamine (DMT). 3GIGA-Consciousness and Neurology Department, Coma Science Group, University of Liège and University Hospital of Liège, Liège, Belgium. ![]() 2The Computational, Cognitive & Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.1Psychedelic Research Group, Centre for Psychiatry, Department of Medicine, Imperial College London, London, United Kingdom.Christopher Timmermann 1,2*, Leor Roseman 1,2, Luke Williams 1, David Erritzoe 1, Charlotte Martial 3, Héléna Cassol 3, Steven Laureys 3, David Nutt 1 and Robin Carhart-Harris 1
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